INVESTIGATION OF THE RADIOPROTECTIVE EFFECT OF ORTHOVANADATE IN MICE AFTER TOTAL BODY IRRADIATION. Issue 2 (11th November 2019)

• Record Type: Journal Article
• Authors: Šinkorová, Zuzana; Filipová, Alžběta; Vávrová, Jiřina; Pejchal, Jaroslav; Andrejsová, Lenka; Jeličová, Marcela; Marek, Jan; Havelek, Radim; Seifrtová, Martina; Řezáčová, Martina; Tichý, Aleš
• Is Part Of: Radiation protection dosimetry. Volume 186:Issue 2/3(2019)
• Page Start: 149
• Page End: 154
• Publication Date: 2019-11-11
• Subjects: Radiation dosimetry -- Periodicals; Radiation -- Safety measures -- Periodicals; 363.1799
• DOI: 10.1093/rpd/ncz192
• Languages: English
• ISSNs: 0144-8420

Abstract

Abstract: The increasing risk of acute large-scale exposure of ionising irradiation on the population underlines the necessity of developing effective radioprotective and mitigating agents. The aim of this work was to investigate the effect of sodium orthovanadate pre-treatment on mice exposed to high doses of gamma rays (from 5 to 13 Gy). The determination of median lethal dose within 30 days confirmed that orthovanadate applied to total-body-irradiated mice intra-peritoneally has a radioprotective but not a mitigating effect. With orthovanadate pre-treatment, the composition of cellularity in the bone marrow improved substantially and the main lymphocyte populations restored during the first month after irradiation. These findings contribute to 'gap-filling' in radioprotective effects and demonstrate the importance of haematological parameters in radiation–response prediction.