CHANGES IN BLOOD COUNT AND LYMPHOCYTE MICRONUCLEI IN PIGLETS AFTER WHOLE-BODY IRRADIATION. Issue 2 (11th November 2019)

• Record Type: Journal Article
• Authors: Jeličová, Marcela; Lierová, Anna; Šinkorová, Zuzana; Pejchal, Jaroslav
• Is Part Of: Radiation protection dosimetry. Volume 186:Issue 2/3(2019)
• Page Start: 176
• Page End: 180
• Publication Date: 2019-11-11
• Subjects: Radiation dosimetry -- Periodicals; Radiation -- Safety measures -- Periodicals; 363.1799
• DOI: 10.1093/rpd/ncz198
• Languages: English
• ISSNs: 0144-8420

Abstract

Abstract: Biodosimetry is focused on effects of ionizing radiation at cellular and molecular levels of living organisms so that a qualified retrospective estimate of radiation load can be made. Two biodosimetry methods were evaluated in irradiated piglets: complete blood count analysis and quantification of chromosomal aberrations in lymphocytes using a micronucleus test. Animals were whole-body irradiated with gamma radiation at doses of 0–10 Gy. The analysis of complete blood count was performed at intervals ranging from 0 to 48 hours. Micronuclei were measured at 4 hours after irradiation. Changes in lymphocyte counts and increased levels of micronuclei reflected received dose of ionizing radiation.