Copper-catalyzed radical cascade cyclization for synthesis of CF3-containing tetracyclic benzimidazo[2, 1-a]iso-quinolin-6(5H)-ones. Issue 2 (22nd December 2020)

• Record Type: Journal Article
• Authors: Sun, Kai; Li, Guofeng; Guo, Sa; Zhang, Zhiguo; Zhang, Guisheng
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 2(2020)
• Page Start: 375
• Page End: 378
• Publication Date: 2020-12-22
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02210a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A practical copper-catalyzed radical cascade carbocyclization reaction was developed for the preparation of a variety of structurally diverse CF3 -containing tetracyclic core benzimidazo[2, 1- a ]isoquinoline-6(5 H )-ones. Abstract : Here, a general copper-catalyzed radical cascade carbocyclization reaction with 2-arylbenzoimidazoles and a Togni reagent was realized. Structurally diverse CF3 -containing tetracyclic core benzimidazo[2, 1- a ]isoquinoline-6(5 H )-ones were obtained in moderate to good yields. The wide substrate scope, good functional group tolerance, and ease of scale-up of this method are expected to promote its potential applications in pharmacy and biotechnology.