Systemic Toxoplasmosis in a Horse. (January 2021)

• Record Type: Journal Article
• Authors: Kimble, Katelyn M.; Gomez, Gabriel; Szule, Joseph A.; Dubey, Jitender P.; Buchanan, Ben; Porter, Brian F.
• Is Part Of: Journal of comparative pathology. Volume 182(2021)
• Page Start: 27
• Page End: 31
• Publication Date: 2021-01
• Subjects: horses -- lymph node -- Toxoplasma gondii -- toxoplasmosis; Veterinary pathology -- Periodicals; Veterinary therapeutics -- Periodicals; Pathology, Comparative -- Periodicals; Therapeutics -- Periodicals; Pathology, Veterinary -- Periodicals; 636.089607
• DOI: 10.1016/j.jcpa.2020.11.004
• Languages: English
• ISSNs: 0021-9975

Abstract

Summary: An adult American Quarter Horse gelding with a history of weight loss presented with an acute onset of colic, fever, soft faeces and elevated liver enzymes. At necropsy, there were gastric mucosal masses and evidence of caecal necrosis. Histologically, the masses were lymph nodes with granulomatous inflammation and areas of liquefactive necrosis. Within and surrounding necrotic areas were free and intrahistiocytic clusters of protozoal tachyzoites. Similar but milder inflammation was evident in the spleen, lungs and liver. Necrotizing typhlitis was also evident. Immunolabelling for Toxoplasma gondii was positive and the ultrastructural morphology of the protozoa was compatible with T. gondii . Although studies have shown seropositivity to T. gondii in horses throughout the world, this is the first report of clinical toxoplasmosis in this species.