A Bayesian approach to improving spatial estimates of prevalence of COVID-19 after accounting for misclassification bias in surveillance data in Philadelphia, PA. (February 2021)

• Record Type: Journal Article
• Authors: Goldstein, Neal D.; Wheeler, David C.; Gustafson, Paul; Burstyn, Igor
• Is Part Of: Spatial and spatio-temporal epidemiology. Volume 36(2021)
• Publication Date: 2021-02
• Subjects: SARS-CoV-2 -- COVID-19 -- Surveillance -- Misclassification -- Bayesian analysis; ADI Area Deprivation Index -- COVID-19 Coronavirus Disease 2019 -- PCR Polymerase Chain Reaction -- SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus 2; Epidemiology -- Statistical methods -- Periodicals; Epidemiology -- Periodicals; 614.4072
• DOI: 10.1016/j.sste.2021.100401
• Languages: English
• ISSNs: 1877-5845

Abstract

Highlights: Surveillance data obtained by public health agencies for COVID-19 are biased. Bayesian approaches can be used to adjust for misclassification bias in surveillance data. Misclassification alone does not explain spatial heterogeneity in COVID-19. Abstract: Surveillance data obtained by public health agencies for COVID-19 are likely inaccurate due to undercounting and misdiagnosing. Using a Bayesian approach, we sought to reduce bias in the estimates of prevalence of COVID-19 in Philadelphia, PA at the ZIP code level. After evaluating various modeling approaches in a simulation study, we estimated true prevalence by ZIP code with and without conditioning on an area deprivation index (ADI). As of June 10, 2020, in Philadelphia, the observed citywide period prevalence was 1.5%. After accounting for bias in the surveillance data, the median posterior citywide true prevalence was 2.3% when accounting for ADI and 2.1% when not. Overall the median posterior surveillance sensitivity and specificity from the models were similar, about 60% and more than 99%, respectively. Surveillance of COVID-19 in Philadelphia tends to understate discrepancies in burden for the more affected areas, potentially misinforming mitigation priorities.