Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?. Issue 5 (November 2020)

• Record Type: Journal Article
• Authors: Gousseff, Marie; Penot, Pauline; Gallay, Laure; Batisse, Dominique; Benech, Nicolas; Bouiller, Kevin; Collarino, Rocco; Conrad, Anne; Slama, Dorsaf; Joseph, Cédric; Lemaignen, Adrien; Lescure, François-Xavier; Levy, Bruno; Mahevas, Matthieu; Pozzetto, Bruno; Vignier, Nicolas; Wyplosz, Benjamin; Salmon, Dominique; Goehringer, Francois; Botelho-Nevers, Elisabeth
• Is Part Of: Journal of infection. Volume 81:Issue 5(2020)
• Page Start: 816
• Page End: 846
• Publication Date: 2020-11
• Subjects: Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2020.06.073
• Languages: English
• ISSNs: 0163-4453

Abstract

Summary: For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.