Characterizing the subtype of anhedonia in major depressive disorder: A symptom-specific multimodal MRI study. (28th February 2021)

• Record Type: Journal Article
• Authors: Liu, Xiaodan; Li, Lingsheng; Li, Meng; Ren, Zepu; Ma, Ping
• Is Part Of: Psychiatry research. Volume 308(2021)
• Publication Date: 2021-02-28
• Subjects: Major depressive disorder (MDD) -- Anhedonia -- Projection-based thickness (PBT) -- Amplitude of low-frequency fluctuations (ALFF) -- Temporal experience of pleasure scale (TEPS); Psychiatry -- Periodicals; Brain -- Imaging -- Periodicals; Psychiatry -- Periodicals; Diagnostic Imaging -- Periodicals; Psychiatrie -- Périodiques; Cerveau -- Imagerie pour le diagnostic -- Périodiques; 616.890754
• DOI: 10.1016/j.pscychresns.2020.111239
• Languages: English
• ISSNs: 0925-4927

Abstract

Highlights: Anhedonia can be divided into consummatory anhedonia and anticipatory anhedonia in MDD. Discrete pathophysiological basis underlying the subtypes of anhedonia in MDD. The ALFF and CT values of ACC and OFC served as the imaging biomarkers of the subtypes of anhedonia in MDD. Abstract: Anhedonia is a core symptom of major depressive disorder (MDD). Two subtypes of anhedonia: anticipatory anhedonia and consummatory anhedonia has been recognized in MDD patients. However, our knowledge regarding the distinction of anticipatory anhedonia and consummatory anhedonia in MDD remains limited. This study aimed to characterize the anticipatory anhedonia and consummatory anhedonia in first-episode, drug-naïve MDD patients. Resting-state functional MRI and T1-structural MRI were acquired for 38 MDD patients and 65 matched healthy controls (HCs). The ALFF and cortical surface indexes were compared between MDD and HCs. Then the correlations between the ALFF and cortical surface indexes alternations and the scores of anticipatory and consummatory pleasure measured by Temporal Experience of Pleasure Scale were evaluated. The elevated ALFF of left dorsal anterior cingulate cortex (dACC) and the reduced cortical thickness (CT) of left rostral ACC and lateral orbitofrontal cortex (lOFC) were respectively correlated with anticipatory anhedonia and consummatory anhedonia in MDD patients. These findings suggested the dissociated pathophysiological basis and imaging characteristics of anticipatory anhedonia and consummatory anhedonia. The ALFF and CT values of ACC and lOFC might serve as the imaging biomarker of the subtypes of anhedonia in early onset of MDD.