Versatile Sensor Modified with Gold Nanoparticles Carbon Paste Electrode for Anodic Stripping Determination of Brexpiprazole: A Voltammetric Study. Issue 12 (15th July 2019)

• Record Type: Journal Article
• Authors: Abdel-Raoof, Ahmed M.; El-Shal, Manal A.; Said, Ragab A. M.; Abostate, Mona H.; Morshedy, Samir; Emara, Mohamed S.
• Is Part Of: Journal of the Electrochemical Society. Volume 166:Issue 12(2019)
• Page Start: B948
• Page End: B955
• Publication Date: 2019-07-15
• Subjects: Sensors -- Differential Pulse -- gold nanoparticles -- Square Wave; Electrochemistry -- Periodicals; 541.3705
• DOI: 10.1149/2.0631912jes
• Languages: English
• ISSNs: 0013-4651

Abstract

Abstract : A variety of voltammetric methods have been carried out for determination of brexpiprazole (BRX) using cyclic voltammetry (CV) and two different type anodic stripping methods; differential pulse (AS-DP) and square wave (AS-SWV) at modified carbon paste electrode with gold nanoparticles (AuNPs-CPEs ). Additionally, electrochemical impedance spectroscopy (EIS) technique has been utilized for characterization of the different electrodes. Electrochemical oxidation behavior of BRX shows an irreversible anodic peak at 0.88 V versus Ag/AgCl, in Britton–Robinson buffer (BR) at pH 4.0, 50s preconcentration time and −0.5 deposition potential. Rectilinear relationship between the peak current versus concentration was obtained over the ranges of 1.32 × 10 −6 –6.45 × 10 −6 and 1.32 × 10 −7 – 6.45 × 10 −7 mol L −1 for AS-DP and AS-SWV respectively. The lowest concentration that can be detected for both for AS-DP and AS-SWV was 3.99 × 10 −7 and 3.32 × 10 −8 mol L −1 respectively; the utilized methods have been devoted adequately for the estimation of BRX in its pure and dosage form.