Triple negative breast cancer in the era of miRNA. (January 2021)

• Record Type: Journal Article
• Authors: Sabit, Hussein; Cevik, Emre; Tombuloglu, Huseyin; Abdel-Ghany, Shaimaa; Tombuloglu, Guzin; Esteller, Manel
• Is Part Of: Critical reviews in oncology/hematology. Volume 157(2021)
• Publication Date: 2021-01
• Subjects: 3′-UTR 3′-Untranslated regions -- AD Alzheimer's disease -- AMO anti-miRNA oligonucleotide -- ASO anti-sense oligonucleotides -- AVV adeno-associated viruses -- BC breast cancer -- CSCs cancer Stem Cells -- CDKs cyclin-dependent kinases -- CPEB cytoplasmic polyadenylation element-binding -- DFS disease-free survival -- DNTMs DNA methyltransferases -- EMT epithelial-to-mesenchymal transition -- ER estrogen receptor -- EMA European medicines agency -- FIH-1 factor-inhibiting HIF1 -- HATs histone acetyltransferase -- HDACs histone deacetylases -- HER2 human epidermal growth factor receptor 2 -- HIF hypoxia-inducible factor -- HOXD10 homeobox D10 -- IRS1 insulin receptor substrate 1 -- LAMC1 laminin subunit gamma 1 -- MET mesenchymal-to-epithelial transition -- miRNA microRNA -- NPs nanoparticles -- OS overall survival -- PCD programmed cell death -- PKCα protein kinase Cα -- PD Parkinson disease -- PR progesterone receptor -- pre-miRNA precursor miRNA -- pri-miRNA primary miRNA -- PI3K phosphatidylinositol-3-kinase -- PTEN phosphatase and tensin homolog -- PD-L1 programmed cell death ligand1 -- RFS Relapse-free survival -- RISC RNA-induced silencing complex -- siRNA small interfering RNA -- SETBP1 SET binding protein 1 -- TIMP TIMP metallopeptidase inhibitor -- TNBC Triple negative breast cancer -- TPM1 tropomyosin 1 -- US FDA US Food and Drug Administration -- XIAP X-linked inhibitor of apoptosis -- VEGF vascular endothelial growth factor; Triple negative breast cancer -- MicroRNAs -- Epigenomics -- Neoplasm -- Metastasis; Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2020.103196
• Languages: English
• ISSNs: 1040-8428

Abstract

Graphical abstract: Abstract: The objective of this review is to elucidate the role of miRNAs in triple negative breast cancer (TNBC). To achieve our goal, we searched databases such as PubMed, ScienceDirect, Springer, Web of Science and Scopus. We retrieved up to 1233 articles, based a rigorous selection criterion, only 197 articles were extensively reviewed. We selected articles only addressing TNBC, but not other types of breast cancer, with the employed approach being miRNA analysis and/or profiling. Our extensive review resulted in grouping of miRNAs into categories in which specific members of miRNAs have roles in specific mechanism in TNBC i.e., carcinogenesis, invasion, metastasis, apoptosis, diagnosis, prognosis, and treatment. TNBC is an aggressive subtype of breast cancer; therefore, different approaches for accurate diagnosis, prognosis and treatment are needed. In this review we summarize the up-to-date miRNA profiling, prognostic, and therapeutic findings that add to the route of controlling TNBC.