3D X-ray micro-computed tomography imaging for the microarchitecture evaluation of porous metallic implants and scaffolds. (March 2021)

• Record Type: Journal Article
• Authors: Liu, Yuchuan; Xie, Dongyang; Zhou, Rifeng; Zhang, Yuxin
• Is Part Of: Micron. Volume 142(2021)
• Publication Date: 2021-03
• Subjects: Micro-CT imaging -- Porous metallic implants -- Microarchitecture analysis -- Bone formation evaluation; Microscopy -- Periodicals; Electron Probe Microanalysis -- Periodicals; Microscopy -- Periodicals; Microscopie -- Périodiques; Microscopy; Periodicals; 502.82
• DOI: 10.1016/j.micron.2020.102994
• Languages: English
• ISSNs: 0968-4328

Abstract

Graphical abstract: Highlights: Micro-CT image provides more microarchitectural information of porous metallic implant. Many good results have been achieved in the Micro-CT assessment of bone formation. The connection between microarchitecture and bone formation is established by Micro-CT. Micro-CT will provide stronger support for the research of implant. Abstract: As an advanced microscopy technology with strong sample adaptability and non-destructive three-dimensional (3D) characteristics, X-ray micro-computed tomography (Micro-CT) can establish the overall connection between various microarchitecture parameters and accelerate the research process of porous metallic implants and scaffolds. In this review, the Micro-CT based quantitative evaluation methods of microarchitecture and bone formation are investigated. To ensure reliability of the results, the Micro-CT setup is discussed briefly and the essential image processing algorithms are introduced in detail. The significance and limitations of Micro-CT are analyzed in the context of research on porous metallic implants. We also discuss the future development of Micro-CT technology in the field of biological tissue engineering.