Bis-morpholinophosphorylchloride, a novel reagent for the conversion of primary amides into nitriles. (2nd February 2021)

• Record Type: Journal Article
• Authors: Rao, P. Purnachandra; Nowshuddin, Shaik; Jha, Anjali; Rao, B. Leela Maheswara; Divi, Murali K.; Rao, M.N.A.
• Is Part Of: Tetrahedron letters. Volume 64(2021)
• Publication Date: 2021-02-02
• Subjects: Bis-morpholinophosphorylchloride -- Dehydration -- Primary amide -- Nitrile; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.152747
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Easy workup. Simple and mild conditions. No racemization. Stable solid reagent. Abstract: Bis-morpholinophosphorylchloride (Bmpc), in the presence of a base, is an efficient dehydrating agent for both aromatic and aliphatic primary amides, and gives corresponding nitriles under mild conditions in god yields and purity. During the reaction the enantiomeric integrity remains intact.