Chemical constituents from Psychotria arborea Hiern (Rubiaceae). (February 2021)

• Record Type: Journal Article
• Authors: Ngo Nyobe, Judith Caroline; Tekapi Tsopgni, Willifred Dongmo; Longue Ekon, Jean Pierre; Ben Saida, Ali; Djuidje, Annie Guilaine; Bengondo, Anicet Biwole; Etame Loe, Gisele; Berionni, Guillaume; Mama, Desire Bikele; Ndom, Jean Claude; Mpondo, Emmanuel Mpondo
• Is Part Of: Biochemical systematics and ecology. Volume 94(2021)
• Publication Date: 2021-02
• Subjects: Rubiaceae -- Psychotria arborea -- Anthraquinones -- 2-Methylanthracene-9, 10-dione -- Antibacterial activities; Chemotaxonomy -- Periodicals; Biochemical variation -- Periodicals; Ecology -- Periodicals; Biochemistry -- Periodicals; Ecology -- Periodicals; Chimiotaxinomie -- Périodiques; Variation biochimique -- Périodiques; Écologie -- Périodiques; 578.012
• DOI: 10.1016/j.bse.2020.104212
• Languages: English
• ISSNs: 0305-1978

Abstract

Abstract: The chemical study of the stems extract of Psychotria arborea Hiern led to the isolation of thirteen compounds, including four anthraquinones: 2-methylanthracene-9, 10-dione (1 ), 2-methoxyanthracene-9, 10-dione (2 ), 2-hydroxy-3-methylanthracene-9, 10-dione (3 ) and 3-hydroxy-1-methoxy-2-methylanthracene-9, 10-dione (4 ); two diterpenes: ent-kaur-16-en-19-oic acid (5 ) and 15-acetoxy-ent-kaur-16-en-19-oic acid (6 ); two triterpenes, β- amyrin (8 ) and oleanolic acid (9 ), one flavonoid: Quercetin (7 ), three sterols: A mixture of stigmasterol (10 ) and β-sitosterol (11 ) and β -sitosterol-3- O -β- D -glucopyranoside (12 ) and one fatty acid (13 ). The structures of these compounds were elucidated based on NMR and HR-ESIMS analysis, further supported by comparison with previously reported spectral data. Compounds 1 –4 and compounds 10 –12 were tested for their antibacterial activity against three bacteria strains Escherichia coli, Staphylococcus aureus and Salmonella enterica . All these tested compounds were found to be inactive. Furthermore, the chemotaxonomic significance of the obtained compounds was discussed in detail. Graphical abstract: Leaves and Twig of P. arborea . Image 1 Highlights: First report of compounds from Psychotria arborea Hiern (Rubiaceae). First report of compound 1 –4 from genus Psychotria . Discussion of the chemotaxonomic significance of the isolated compounds. Antimicrobial assay of the isolated compounds.