Contribution of AMPA and NMDA receptors in the spontaneous firing patterns of single neurons in autaptic culture. (December 2020)

• Record Type: Journal Article
• Authors: Hattori, Kouhei; Hayakawa, Takeshi; Nakanishi, Akira; Ishida, Mihoko; Yamamoto, Hideaki; Hirano-Iwata, Ayumi; Tanii, Takashi
• Is Part Of: Bio systems. Volume 198(2020)
• Publication Date: 2020-12
• Subjects: Neuron -- Autapse -- AMPA and NMDA receptors -- Micropatterning technique -- Coincidence detection; Biological systems -- Periodicals; Biology -- Periodicals; Biology -- Periodicals; Evolution -- Periodicals; Biologie -- Périodiques; Évolution -- Périodiques; 570
• DOI: 10.1016/j.biosystems.2020.104278
• Languages: English
• ISSNs: 0303-2647

Abstract

Abstract: Single neurons in an autaptic culture exhibit various types of firing pattern with different firing durations and rhythms. However, a neuron with autapses has often been modeled as an oscillator providing a monotonic firing pattern with a constant periodicity because of the lack of a mathematical model. In the work described in this study, we use computational simulation and whole-cell patch-clamp recording to elucidate and model the mechanism by which such neurons generate various firing pattens. In the computational simulation, three types of spontaneous firing pattern, i.e., short, long-lasting, and periodic burst firing patterns are realized by changing the combination ratio of N -methyl- d -aspartate (NMDA) to α -amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) conductance. These three types of firing patterns are also observed in the experiments where neurons are cultured in isolation on micropatterned substrates. Using the AMPA and NMDA current models, we discuss that, in principle, autapses can regulate rhythmicity and information selection in neuronal networks. Graphical abstract: Highlights: A mathematical model for single neurons in an autaptic culture is proposed. The model provides three types of firing pattern depending on the combination ratio of AMPA and NMDA conductance. The simulated spontaneous firing patterns agree with the results from physiological experiments.