Eliciting carbohydrate-specific immune response against sialosides: success and challenges. (April 2011)

• Record Type: Journal Article
• Authors: Ling, Chang-Chun; Bundle, David R
• Is Part Of: Future medicinal chemistry. Volume 3:Number 5(2011)
• Page Start: 519
• Page End: 534
• Publication Date: 2011-04
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.4155/fmc.11.28
• Languages: English
• ISSNs: 1756-8919

Abstract

Chemoenzymatic synthesis has been shown to be a powerful adjunct to carbohydrate chemistry since it allows chemists to prepare a wide range of complex carbohydrate analogs in large amounts and with unparalleled efficiency. Here we summarize investigations conducted in our group into the synthesis and immunochemistry of tumor-associated gangliosides and the development of a chemoenzymatic route to αα(2→→8)-linked oligosialosides by probing substrate binding to the enzyme, αα(2→→8)-sialyltransferase.