A label-free enrofloxacin electrochemical aptasensor constructed by a semiconducting CoNi-based metal–organic framework (MOF). (1st February 2021)

• Record Type: Journal Article
• Authors: Song, Yingpan; Xu, Miaoran; Liu, Xiao; Li, Zhenzhen; Wang, Changbao; Jia, Qiaojuan; Zhang, Zhihong; Du, Miao
• Is Part Of: Electrochimica acta. Volume 368(2021)
• Publication Date: 2021-02-01
• Subjects: Semiconducting MOF -- Graphene-like nanostructure -- Electrochemical aptasensor -- Enrofloxacin -- Trace detection; Electrochemistry -- Periodicals; Electrochemistry, Industrial -- Periodicals; 541.37
• DOI: 10.1016/j.electacta.2020.137609
• Languages: English
• ISSNs: 0013-4686

Abstract

Highlights: A semiconducting bimetallic MOF material with 2D graphene-like nanostructure. Strong aptamer immobilization and ultrasensitive detection of enrofloxacin. Superior sensing performances on selectivity, reproducibility, stability, and applicability. New aptasensing strategy on MOFs-based electrochemical biosensors. Abstract: A semiconducting CoNi-based metal–organic framework (MOF), Cox Ni3-x (HITP)2, was designed and synthesized using 2, 3, 6, 7, 10, 11-hexaaminotriphenylene (HATP) as organic linker. Compared with Co3 (HITP)2 and Ni3 (HITP)2, Cox Ni3-x (HITP)2 possesses mixed metal valences of Co 2+ /Co 3+ /Ni 2+ /Ni 3+ and more defects within the MOF skeleton, which also shows amino-rich functionality, biocompatibility, and the intrinsic features of semiconducting MOFs, such as two-dimensional graphene-like nanostructure, high stability in water solution, and good electrochemical activity. As a consequence, the Cox Ni3-x (HITP)2 -based electrochemical aptasensor demonstrates superior sensing performances for enrofloxacin, with an extremely low detection limit of 0.2 fgmL −1 and a linear range of 0.001−1 pgmL −1, as well as high selectivity, excellent reproducibility, good stability, and wide applicability. The developed sensing strategy provides new insights into the fabrication of MOFs-based sensors for food safety, environment protection, and medical diagnosis. Graphical abstract: Image, graphical abstract