On-line monitoring human breath acetone during exercise and diet by proton transfer reaction mass spectrometry. (26th November 2018)

• Record Type: Journal Article
• Authors: Zou, Xue; Wang, Hongmei; Ge, Dianlong; Lu, Yan; Xia, Lei; Huang, Chaoqun; Shen, Chengyin; Chu, Yannan
• Is Part Of: Bioanalysis. Volume 11:Number 1(2019)
• Page Start: 33
• Page End: 40
• Publication Date: 2018-11-26
• Subjects: breath -- MS -- method development; Drugs -- Analysis -- Periodicals; 615.19005
• DOI: 10.4155/bio-2018-0258
• Languages: English
• ISSNs: 1757-6180

Abstract

Aim: This study aims to develop a method for monitoring fat loss by detection of breath acetone.Methods: A new method combining direct breath sampling system and proton transfer reaction MS (PTR-MS) was developed for on-line detection of breath acetone. The breath acetone of 272 volunteers was detected respectively when exercise or diet.Results: Exercises perennially can make the breath acetone increase by 40–130%. Dinner fasting for 1 week can make it increase by 140%.Conclusion: Exercise and diet are two useful methods to lose fat. Determination of breath acetone concentration using the direct breath sampling system-proton transfer reaction MS can help design scheme of exercise and diet for losing weight.