The diverse and unanticipated roles of histone deacetylase 9 in coordinating plant development and environmental acclimation. (20th July 2020)

• Record Type: Journal Article
• Authors: de Rooij, Peter G H; Perrella, Giorgio; Kaiserli, Eirini; van Zanten, Martijn
• Editors: Gibbs, Daniel
• Is Part Of: Journal of experimental botany. Volume 71:Number 20(2020)
• Page Start: 6211
• Page End: 6225
• Publication Date: 2020-07-20
• Subjects: ABA INSENSITIVE 4 (ABI4) -- Arabidopsis -- EARLY FLOWERING 3 (ELF3) -- gene regulation -- HDA9 -- histone deacetylase 9 -- HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 15 (HOS15) -- ELONGATED HYPOCOTYL 5 (HY5) -- POWERDRESS (PWR) -- WRKY53; Botany -- Periodicals; Botany, Experimental -- Periodicals; Plant physiology -- Periodicals; 580
• DOI: 10.1093/jxb/eraa335
• Languages: English
• ISSNs: 0022-0957

Abstract

Abstract : We discuss the contribution of the versatile and atypical plant histone deacetylase, HDA9, to plant growth, development, and acclimation to the environment, and propose novel leads for future research. Abstract: Plants tightly control gene transcription to adapt to environmental conditions and steer growth and development. Different types of epigenetic modifications are instrumental in these processes. In recent years, an important role for the chromatin-modifying RPD3/HDA1 class I HDAC HISTONE DEACETYLASE 9 (HDA9) emerged in the regulation of a multitude of plant traits and responses. HDACs are widely considered transcriptional repressors and are typically part of multiprotein complexes containing co-repressors, DNA, and histone-binding proteins. By catalyzing the removal of acetyl groups from lysine residues of histone protein tails, HDA9 negatively controls gene expression in many cases, in concert with interacting proteins such as POWERDRESS (PWR), HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 15 (HOS15), WRKY53, ELONGATED HYPOCOTYL 5 (HY5), ABA INSENSITIVE 4 (ABI4), and EARLY FLOWERING 3 (ELF3). However, HDA9 activity has also been directly linked to transcriptional activation. In addition, following the recent breakthrough discovery of mutual negative feedback regulation between HDA9 and its interacting WRKY-domain transcription factor WRKY53, swift progress in gaining understanding of the biology of HDA9 is expected. In this review, we summarize knowledge on this intriguing versatile—and long under-rated—protein and propose novel leads to further unravel HDA9-governed molecular networks underlying plant development and environmental biology.