Rapid Involution of Large Cardiac Rhabdomyomas With Everolimus Therapy. Issue 3 (May 2021)

• Record Type: Journal Article
• Authors: Garg, Ashish; Gorla, Sudheer R.; Kardon, Richard E.; Swaminathan, Sethuraman
• Is Part Of: World journal for pediatric & congenital heart surgery. Volume 12:Issue 3(2021)
• Page Start: 426
• Page End: 429
• Publication Date: 2021-05
• Subjects: Pediatric cardiology -- Periodicals; Congenital heart disease in children -- Periodicals; Heart -- Abnormalities -- Surgery -- Periodicals; Heart -- Surgery -- Periodicals; Heart Defects, Congenital -- surgery -- Periodicals; Cardiac Surgical Procedures -- Periodicals; Child -- Periodicals; Adult -- Periodicals; 618.9212
• DOI: 10.1177/2150135118822711
• Languages: English
• ISSNs: 2150-1351

Abstract

Rhabdomyoma of the fetal heart is a rare disease accounting for about 1% of all fetal cardiac structural anomalies. They are often found in association with tuberous sclerosis complex. Large cardiac rhabdomyomas can compromise the cardiac function. We report a case of multiple large rhabdomyomas of the right and left ventricles, affecting the cardiac function, which was successfully treated with the chemotherapeutic and immunosuppressive medication everolimus, in a neonate with genetically confirmed tuberous sclerosis complex with multisystem manifestations. There was rapid involution of the tumors in response to everolimus therapy in this infant.