Estimating the glomerular filtration rate in pregnancy: The evaluation of the Nanra and CKD-EPI serum creatinine-based equations. (March 2021)

• Record Type: Journal Article
• Authors: Gao, Michael; Vilayur, Eswari; Ferreira, David; Nanra, Ranjit; Hawkins, Joan
• Is Part Of: Obstetric medicine. Volume 14:Number 1(2021)
• Page Start: 31
• Page End: 34
• Publication Date: 2021-03
• Subjects: Glomerular filtration rate -- pregnancy -- serum creatinine -- creatinine clearance -- Nanra -- CKD-EPI; Pregnancy -- Complications -- Periodicals; Obstetrics -- Periodicals; 618.2
• DOI: 10.1177/1753495X20904177
• Languages: English
• ISSNs: 1753-495X

Abstract

Aim: To compare the performance of the Nanra and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating glomerular filtration rate in pregnancy against the 24 h urine creatinine clearance. Methods: Pregnant women had 24 h urine collections with simultaneous serum creatinine levels. Measured 24 h urine creatinine clearance was compared to two equations: Nanra and CKD-EPI. Level of concordance was measured, with an a priori bias acceptance of ±15 ml/min/1.73 m 2 . Results: A total of 53 synchronous urine and serum creatinine samples were analysed. The Nanra equation had a bias of −13.4 ml/min/1.73 m 2 while the CKD-EPI equation had bias of 14.2 ml/min/1.73 m 2 . Both equations showed a high degree of proportional error and had poor agreement with 24 h urine creatinine clearance. Conclusions: None of the equations were shown to reliably measure the estimated glomerular filtration rate in pregnant women. A valid serum creatinine-based estimated glomerular filtration rate equation in pregnancy is yet to be established.