Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE. (9th July 2020)

• Record Type: Journal Article
• Authors: Umbleja, Triin; Brown, Todd T; Overton, Edgar T; Ribaudo, Heather J; Schrack, Jennifer A; Fitch, Kathleen V; Douglas, Pamela S; Grinspoon, Steven K; Henn, Sarah; Arduino, Roberto C; Rodriguez, Benigno; Benson, Constance A; Erlandson, Kristine M
• Is Part Of: Journal of infectious diseases. Volume 222(2020)Supplement 1
• Page Start: S52
• Page End: S62
• Publication Date: 2020-07-09
• Subjects: HIV -- Aging -- Physical function -- Frailty -- SPPB; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa249
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: People with human immunodeficiency virus (PWH) are at risk for accelerated development of physical function impairment and frailty; both associated with increased risk of falls, hospitalizations, and death. Identifying factors associated with physical function impairment and frailty can help target interventions. Methods: The REPRIEVE trial enrolled participants 40–75 years of age, receiving stable antiretroviral therapy with CD4 + T-cell count >100 cells/mm3, and with low to moderate cardiovascular disease risk. We conducted a cross-sectional analysis of those concurrently enrolled in the ancillary study PREPARE at enrollment. Results: Among the 266 participants, the median age was 51 years; 81% were male, and 45% were black, and 28% had hypertension. Body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) was 25 to <30 in 38% and ≥30 in 30%, 33% had a high waist circumference, 89% were physically inactive, 37% (95% confidence interval, 31%, 43%) had physical function impairment (Short Physical Performance Battery score ≤10), and 6% (4%, 9%) were frail and 42% prefrail. In the adjusted analyses, older age, black race, greater BMI, and physical inactivity were associated with physical function impairment; depression and hypertension were associated with frailty or prefrailty. Conclusions: Physical function impairment was common among middle-aged PWH; greater BMI and physical inactivity are important modifiable factors that may prevent further decline in physical function with aging. Clinical Trials Registration: NCT02344290.