Association of Time in Range levels with Lower Extremity Arterial Disease in patients with type 2 diabetes. Issue 6 (November 2020)

• Record Type: Journal Article
• Authors: Li, Jinfeng; Li, Ya; Ma, Weiguo; Liu, Yishan; Yin, Xiaohong; Xie, Chuanqing; Bai, Jiao; Zhang, Min
• Is Part Of: Diabetes & metabolic syndrome. Volume 14:Issue 6(2020)
• Page Start: 2081
• Page End: 2085
• Publication Date: 2020-11
• Subjects: Diabetic lower artery extremity disease -- Type 2 diabetes -- Time in range -- Continuous glucose monitoring; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2020.09.028
• Languages: English
• ISSNs: 1871-4021

Abstract

OBJECTIVE: Background and aims: Time in range (TIR) is a new metric of glycemic control, assessed by continuous glucose monitoring (CGM). Previous studies have shown that is associated with microvascular complications of diabetes. We aimed to investigate the relationship between TIR levels and Lower Extremity Arterial Disease (LEAD) in patients with type 2 diabetes (T2DM). Methods: This cross-sectional study evaluated a total of 336 patients with T2DM, including 179 patients with LEAD and 157 without patients. Analysis of covariance was performed after adjusting for confounders. A logistic regression model was used to evaluate the relationship between TIR levels and LEAD. Results: The results of our tests indicate that TIR levels were significantly lower in T2DM with LEAD than in those without (73.05 ± 18.13 versus 65.62 ± 16.43, P < 0.01). Furthermore, the prevalence of LEAD by severity decreased with ascending quartiles of TIR (P < 0.05). After adjusting for other covariates, TIR were independent determinants for LEAD occurrence in patients with T2DM (OR = 0.979, 95%CI: 0.965, 0.992) and the TIR levels were significantly different according to the severity of LEAD. Conclusions: TIR is significantly and independently associated with diabetic lower artery extremity disease in Type 2 Diabetes. We suggest that TIR should be more broadly accepted as a research endpoint or clinical measure. Highlights: Time in range may be the first index to predict the risk of diabetic complications and to evaluate the glycemic control. Time in range is significantly and independently associated with diabetic lower artery extremity disease in Type 2 Diabetes. We suggest that Time in range (TIR)should be more broadly accepted as a research end point or clinical measure.