Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata. (4th January 2021)

• Record Type: Journal Article
• Authors: Dang, Phu H.; Le, Tho H.; Do, Truong N. V.; Nguyen, Hai X.; Nguyen, Mai T. T.; Nguyen, Nhan T.
• Other Names: shanak Siba Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2021(2021)
• Publication Date: 2021-01-04
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2021/8872920
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : From a CHCl3 -soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1 ) and semetrienone (2 ), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC50 values of 0.033 and 0.11 μ M, respectively. Docking studies of 1 and 2 with oxy -tyrosinase were carried out to analyze their interactions. Accordingly, semedienone (1 ) showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalkanoids was proposed.