Comparison of changes in albumin binding capacity during hemodiafiltration or hemodialysis with middle cut off membranes. Issue 5 (May 2021)

• Record Type: Journal Article
• Authors: Koball, Sebastian; Westphal, Christina; Frimmel, Silvius; Hinz, Michael; Klammt, Sebastian; Mitzner, Steffen
• Is Part Of: International journal of artificial organs. Volume 44:Issue 5(2021)
• Page Start: 297
• Page End: 301
• Publication Date: 2021-05
• Subjects: Middle cut off dialyzers -- uremic toxins -- albumin bound toxins -- HDx -- extended dialysis -- hemodiafiltration; Artificial organs -- Periodicals; 617.956
• DOI: 10.1177/0391398820961780
• Languages: English
• ISSNs: 0391-3988

Abstract

Background: Albumin is important for the transport of protein-bound substances (PBS). Albumin binding capacity (ABiC) is reduced in dialysis patients. This can contribute to worsening of uremic symptoms. It is presumed that open-porous middle cut off filters that is, HDx (Baxter-Theranova) remove high molecular substances more efficiently than conventional treatment. To evaluate HDx for the improvement of ABiC and removal of PBS, HDx was compared to hemodiafiltration (Fresenius-FX80, HDF). Methods: We included 32 chronic patients on HDF. After inclusion patients were treated with HDx for 14 days. Blood samples were drawn before/after treatments at study entry, first HDx and sixth HDx, to determine ABiC and other study parameters. Results: ABiC improved in HDx (68.4% vs 72.4%) and HDF (69.9% vs 72.4%) without differences between both therapies. No reduction of albumin concentration during HDx treatment was observed. Conclusion: HDx is accepted as a safe and equally efficient therapy for removing albumin bound uremic toxins compared to HDF with high flux dialyzers.