Editor's Choice – Effect of Statins on Total Mortality in Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-analysis. (January 2021)

• Record Type: Journal Article
• Authors: Risum, Øyvind; Sandven, Irene; Sundhagen, Jon O.; Abdelnoor, Michael
• Is Part Of: European journal of vascular and endovascular surgery. Volume 61:Number 1(2021)
• Page Start: 114
• Page End: 120
• Publication Date: 2021-01
• Subjects: Abdominal aortic aneurysm -- Endovascular aneurysm repair -- Long term survival -- Open surgical repair -- Statin therapy; Blood-vessels -- Endoscopic surgery -- Periodicals; Blood-vessels -- Surgery -- Periodicals; Vascular Surgical Procedures -- Periodicals; Vascular Surgical Procedures -- methods -- Periodicals; Vaisseaux sanguins -- Chirurgie -- Périodiques; Vaisseaux sanguins -- Chirurgie endoscopique -- Périodiques; Blood-vessels -- Endoscopic surgery; Blood-vessels -- Surgery; Endoscopy; Electronic journals; Periodicals; Electronic journals; 617.413005
• DOI: 10.1016/j.ejvs.2020.08.007
• Languages: English
• ISSNs: 1078-5884

Abstract

Abstract : Objective: The aim was to summarise the evidence from published epidemiological studies investigating the efficacy of statin therapy on long term survival in patients after abdominal aortic aneurysm (AAA) repair. Data sources: This study was a systematic review with critical appraisal and meta-analysis of observational studies. Review methods: A systematic literature search was carried out throughout February 2020, revealing 14 eligible cohort studies of which 11 were judged to be of high quality. A random effects model was used to synthesise results, and heterogeneity between studies examined by subgroup and meta-regression analyses considering patient and study related variables. Small study effect was evaluated. Results: The pooled estimate showed that statin treatment among 69 790 AAA patients with a median follow up of 3.1 years was associated with a 35% relative reduction in total mortality (rate ratio 0.65, 95% confidence interval 0.57–0.73) with moderate heterogeneity (I 2 = 68%) and no small study effect. Conclusion: Evidence from this systematic review indicates a beneficial effect of statins on long term survival in patients treated by AAA repair.