Effects of hyperbaric oxygen therapy on the healing of thermal burns and its relationship with ICAM-1: A case-control study. (January 2021)

• Record Type: Journal Article
• Authors: Oley, Mendy Hatibie; Oley, Maximillian Christian; Aling, Deanette Michelle R.; Kalangi, Jane Angela; Islam, Andi Asadul; Hatta, Mochammad; Patellongi, Ilham Jaya; Josh, Fonny; Faruk, Muhammad
• Is Part Of: Annals of medicine and surgery. Volume 61(2021)
• Page Start: 104
• Page End: 109
• Publication Date: 2021-01
• Subjects: HBOT -- ICAM-1 -- Healing wounds -- Length of stay -- MRNA expression -- Epithelization; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2020.12.025
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Background: The damaging effects of thermal burns need to be managed holistically in order to create a suitable environment for wound healing. The purpose of our study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on the healing of thermal burns and its relationship with intercellular adhesion molecule 1 (ICAM-1). Methods: Twenty patients with thermal burns were randomly divided into two groups: the group to receive HBOT and the control group. Levels of the ICAM- 1 mRNA gene and ICAM-1 serum along with the degree of wound epithelialization were examined before and after treatment. Laboratory and physical findings between the groups were compared. Results: In the HBOT group compared with the control group, thermal wound complications were significantly reduced ( p = .006), while length of stay in hospital was substantially reduced ( p = .001). ICAM-1 serum levels strongly correlated with ICAM- 1 mRNA gene expression ( R 2 = 0.909, p < .001). The expression of the ICAM- 1 mRNA gene (12.32 ± 1.31 vs. 10.79 ± 1.38) and ICAM-1 serum level (231.46 ± 37.20 vs. 158.23 ± 68.30) in patients with at least a 50% burn area exceeded those of patients with a smaller burn area. HBOT significantly decreased ( p < .05) the expression of the ICAM- 1 mRNA gene and ICAM-1 serum level ( p = .004). The number of HBOT sessions strongly correlated with ICAM-1 serum level ( p = .043) but poorly correlated with ICAM- 1 mRNA gene expression ( p = .22). The expression of the gene, however, strongly correlated with ICAM-1 serum level ( r = −0.988, p < .001). Conclusion: HBOT can reduce thermal wound complications, length of stay in hospitals due to thermal burns, ICAM- 1 mRNA gene expression, and ICAM-1 serum level. Highlights: Thermal burns are serious injuries with detrimental effects that require prompt treatment. The inflammatory process that occurs due to burns increases the production of ICAM-1. HBOT works by increasing the pressure of oxygen such that it can directly diffuse into various tissues. The effects of increased oxygen supply include angiogenesis, increased fibroblast proliferation, and reduced tissue edema. HBOT can reduce thermal wound complications, and length of stay in hospitals.