Synthesis, structure, polyphenol oxidase mimicking and bactericidal activity of a zinc-schiff base complex. (15th January 2021)

• Record Type: Journal Article
• Authors: Mahato, Shreya; Meheta, Nishith; Kotakonda, Muddukrishnaiah; Joshi, Mayank; Shit, Madhusudan; Choudhury, Angshuman Roy; Biswas, Bhaskar
• Is Part Of: Polyhedron. Volume 194(2021)
• Publication Date: 2021-01-15
• Subjects: Zinc(II) -- Elecrochemical analysis -- 4-Methylcatechol oxidation -- Schiff base -- X-ray structure -- Bactericidal activity; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2020.114933
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: This research work demonstrates the synthesis, crystal structure, supramolecular architecture, 4-methylcatechol oxidation and bactericidal activity of a newly designed zinc complex containing a protonated Schiff base of zwitter ion type. Highlights: Synthesis and crystal structure of a tetrahedral zinc-Schiff base complex. Schiff base gets protonated to exhibit monodentate behaviour. The zinc complex exhibits good efficiency towards the bio-mimetic oxidation of 4-methylcatechol. Radical driven catalytic activity has been observed. Shows good bactericidal activity with 1.44% presence of zinc in cell membrane of bacteria. Abstract: Focusing on the important biological functions of metallo-enzymes and metallo-therapeutics in living world, this research work demonstrates the synthesis, crystal structure, supramolecular architecture, 4-methylcatechol oxidation and bactericidal activity of an interesting zinc-Schiff base complex, [Zn(HL )2 Cl2 ] (1), [Schiff base (HL ) = 2-(2-methoxybenzylideneamino)phenol]. Crystal structure analysis of the zinc-Schiff base reveals that zinc centre exists in a distorted tetrahedral geometry. The Schiff base adopts three donor centres, however it gets protonated to exist in a zwitter ionic form and behaves as a monodentate coordinator in 1 . This zinc-Schiff base complex has been examined towards the bio-mimetic oxidation of 4-methylcatechol (4-MC) in methanol and portrays its good efficacy with good turnover number, 1.45 × 10 3 h −1 . Electro-chemical study, electron paramagnetic resonance analysis and electrospray ionization mass spectrometry results for the zinc-Schiff base complex in presence of 4-MC ensures that the catalytic reaction undergoes through enzyme-substrate binding, and generation of radical in the course of catalysis drives the catalytic oxidation of 4-MC. Antibacterial study has also been performed against few clinical pathogens ( Bacillus SP, Enterococcus, and E. coli ). Scanning electron microscope and EDAX analysis for the pathogen with little dose of zinc complex confirms the destruction of bacterial cell membrane with 1.44% occurrence of zinc in the selected zone of inhibition area. This observation holds a great promise to develop future antibacterial agent.