Prospective Study Demonstrates Utility of EP-QuIC in Creutzfeldt–Jakob Disease Diagnoses. (10th January 2021)

• Record Type: Journal Article
• Authors: Simon, Sharon L. R.; Peterson, Anne; Phillipson, Clark; Walker, Jonathan M.; Richmond, Meika; Jansen, Gerard H.; Knox, J. David
• Is Part Of: Canadian journal of neurological sciences. Volume 48:Number 1(2021)
• Page Start: 127
• Page End: 129
• Publication Date: 2021-01-10
• Subjects: Creutzfeldt–Jakob disease, -- Prion, -- RT-QuIC, -- EP-QuIC; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Electronic journals; 616.8
• DOI: 10.1017/cjn.2020.139
• Languages: English
• ISSNs: 0317-1671

Abstract

ABSTRACT: Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the performance characteristics of three ante-mortem tests commonly used to support diagnoses of Creutzfeldt–Jakob disease. The utility of the end-point quaking-induced conversion assay as a test for Creutzfeldt–Jakob disease diagnoses was compared to that of immunoassays designed to detect increased amounts of the surrogate markers 14-3-3γ and hTau. The positive predictive values of the end-point quaking-induced conversion, 14-3-3γ, and hTau tests conducted at the Prion Diseases Section of the Public Health Agency of Canada were 96%, 68%, and 66%, respectively.