Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study. Issue 4 (28th February 2021)

• Record Type: Journal Article
• Authors: Long, Jing-An; Zhong, Rong-Huan; Chen, Si; Wang, Fan; Luo, Yun; Lu, Xiao-Ting; Yishake, Dinuerguli; Chen, Yu-Ming; Fang, Ai-Ping; Zhu, Hui-Lian
• Is Part Of: British journal of nutrition. Volume 125:Issue 4(2021)
• Page Start: 440
• Page End: 447
• Publication Date: 2021-02-28
• Subjects: Dietary betaine, -- Skeletal muscle mass, -- Skeletal muscle index, -- Longitudinal change, -- Prospective cohort studies; Nutrition -- Periodicals; 572.4
• DOI: 10.1017/S0007114520002433
• Languages: English
• ISSNs: 0007-1145

Abstract

Abstract: A higher dietary intake or serum concentration of betaine has been associated with greater lean body mass in middle-aged and older adults. However, it remains unknown whether betaine intake is associated with age-related loss of skeletal muscle mass (SMM). We assessed the association between dietary betaine intake and relative changes in SMM after 3 years in middle-aged adults. A total of 1242 participants aged 41–60 years from the Guangzhou Nutrition and Health Study 2011–2013 and 2014–2017 with body composition measurements by dual-energy X-ray absorptiometry were included. A face-to-face questionnaire was used to collect general baseline information. After adjustment for potential confounders, multiple linear regression found that energy-adjusted dietary betaine intake was significantly and positively associated with relative changes (i.e. percentage loss or increase) in SMM of legs, limbs and appendicular skeletal mass index (ASMI) over 3 years of follow-up ( β 0·322 (se 0·157), 0·309 (se 0·142) and 0·303 (se 0·145), respectively; P < 0·05). The ANCOVA models revealed that participants in the highest betaine tertile had significantly less loss in SMM of limbs and ASMI and more increase in SMM of legs over 3 years of follow-up, compared with those in the bottom betaine tertile (all P trend < 0·05). In conclusion, our findings suggest that elevated higher dietary betaine intake may be associated with less loss of SMM of legs, limbs and ASMI in middle-aged adults.