Exploring the relationship between effort perception and poststroke fatigue. (15th December 2020)

• Record Type: Journal Article
• Authors: De Doncker, William; Charles, Lucie; Ondobaka, Sasha; Kuppuswamy, Annapoorna
• Is Part Of: Neurology. Volume 95:Number 24(2020)
• Publication Date: 2020-12-15
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000010985
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: To test the hypothesis that poststroke fatigue, a chronic, pathologic fatigue condition, is driven by altered effort perception. Methods: Fifty-eight nondepressed, mildly impaired stroke survivors with varying severity of fatigue completed the study. Self-reported fatigue (trait and state), perceived effort (PE; explicit and implicit), and motor performance were measured in a handgrip task. Trait fatigue was measured with the Fatigue Severity Scale-7 and Neurologic Fatigue Index. State fatigue was measured with a visual analog scale (VAS). Length of hold at target force, overshoot above target force, and force variability in handgrip task were measures of motor performance. PE was measured with a VAS (explicit PE) and line length estimation, a novel implicit measure of PE. Results: Regression analysis showed that 11.6% of variance in trait fatigue was explained by implicit PE ( R = 0.34; p = 0.012). Greater fatigue was related to longer length of hold at target force ( R = 0.421, p < 0.001). A backward regression showed that length of hold explained explicit PE in the 20% force condition ( R = 0.306, p = 0.021) and length of hold and overshoot above target force explained explicit PE in the 40% ( R = 0.399, p = 0.014 and 0.004) force condition. In the 60% force condition, greater explicit PE was explained by higher force variability ( R = 0.315, p = 0.017). None of the correlations were significant for state fatigue. Conclusion: Trait fatigue, but not state fatigue, correlating with measures of PE and motor performance, may suggest that altered perception may lead to high fatigue mediated by changes in motor performance. This finding furthers our mechanistic understanding of poststroke fatigue.