Low-dose Aspirin for the Prevention of Preterm Delivery in Nulliparous Women With a Singleton Pregnancy (ASPIRIN): A Randomized, Double-blind, Placebo-controlled Trial. Issue 4 (December 2020)

• Record Type: Journal Article
• Authors: Hoffman, M.K.; Goudar, S.S.; Kodkany, B.S.; Metgud, M.; Somannavar, M.; Okitawutshu, J.; Lokangaka, A.; Tshefu, A.; Bose, C.L.; Mwapule, A.; Mwenechanya, M.; Chomba, E.; Carlo, W.A.; Chicuy, J.; Figueroa, L.; Garces, A.; Krebs, N.F.; Jessani, S.; Zehra, F.; Saleem, S.; Goldenberg, R.L.; Kurhe, K.; Das, P.; Patel, A.; Hibberd, P.L.; Achieng, E.; Nyongesa, P.; Esamai, F.; Liechty, E.A.; Goco, N.; Hemingway-Foday, J.; Moore, J.; Nolen, T.L.; McClure, E.M.; Koso-Thomas, M.; Miodovnik, M.; Silver, R.; Derman, R.J.;
• Is Part Of: Obstetric anesthesia digest. Volume 40:Issue 4(2020)
• Publication Date: 2020-12
• Subjects: Neonatal Morbidity and Mortality -- Pharmacology; Anesthesia in obstetrics -- Periodicals; Anesthesia in obstetrics -- Abstracts -- Periodicals; 617.968205
• DOI: 10.1097/01.aoa.0000719608.24257.dc
• Languages: English
• ISSNs: 0275-665X

Abstract

Abstract : ( Lancet . 2020;395:285–293) Preterm birth is a common cause of infant morbidity and mortality, especially in low- and middle-income countries with limited resources. Previous studies of aspirin used to prevent preeclampsia also suggested that low-dose aspirin may help lower the incidence of preterm births. However, no large-scale trial has specifically evaluated the use of low-dose aspirin initiated in early pregnancy with the primary purpose of preventing preterm birth. The aim of this study (the ASPIRIN trial) was to determine if low-dose aspirin administered daily starting in early pregnancy reduced the incidence of preterm delivery.