Association of malnutrition with postoperative complication risk after curative surgery for oral cancer: Observational study. Issue 52 (24th December 2020)

• Record Type: Journal Article
• Authors: Tsai, Yao-Te; Lai, Chia-Hsuan; Huang, Tzu-Hao; Hsieh, Ching-Chuan; Huang, Ethan I.; Lee, Yi-Chan; Yeh, Hsuan-Keng; Tsai, Ming-Shao; Chang, Geng-He; Hsu, Cheng-Ming
• Other Names: Wang. Shengchun section editor.
• Is Part Of: Medicine. Volume 99:Issue 52(2020)
• Publication Date: 2020-12-24
• Subjects: Clavien–Dindo classification -- malnutrition -- oral cavity squamous cell carcinoma -- patient-generated subjective global assessment (PG-SGA) -- postoperative complication; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000023860
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Malnutrition is common among patients who have oral cavity squamous cell carcinoma (OSCC), but its effect on the incidence of postoperative complications remains uncertain. Validated nutrition and complication assessment tools were used to evaluate the effects of nutrition on the likelihood of postoperative complications after curative surgery for OSCC. A retrospective study that spanned January 2014 to December 2018 enrolled 70 patients who received curative surgery for OSCC. Nutritional status before surgery was evaluated with the scored Patient-Generated Subjective Global Assessment (PG-SGA), and patients were classified as either well-nourished (rating A) or malnourished (ratings B and C). Complications 30 days after the operation were graded using Clavien-Dindo classification. The perioperative clinicopathological characteristics of the groups were compared, and risk factors for postoperative complications were identified through logistic regression. A total of 44 (62.8%) patients formed the malnourished group, and they tended to be older ( P = .03), weigh less ( P = .001), have lower Body Mass Index ( P = .003), higher PG-SGA scores ( P < .001), higher neutrophil-to-lymphocyte ratio ( P = .034), more postoperative complications ( P < .001), and longer hospital stays ( P = .021). Major complications (Clavien–Dindo classification ≥ IIIa) were experienced by 18.5% (n = 13) of patients and were more common in the malnourished group ( P = .007). Multivariate logistic regression demonstrated that PG-SGA score ≥4 was an independent risk factor for postoperative complications (hazard ratio = 4.929, P = .008). Malnutrition defined using the PG-SGA is an independent risk factor for postoperative complications of curative surgery in patients with OSCC. More prospective studies are warranted to confirm our findings.