Cannabis Use Linked to Altered Functional Connectivity of the Visual Attentional Connectivity in Patients With Psychosis and Controls. Issue 1 (20th April 2020)

• Record Type: Journal Article
• Authors: Sami, Musa Basseer; McCutcheon, Robert A; Ettinger, Ulrich; Williams, Steve; Lythgoe, Dave; McGuire, Philip; Bhattacharyya, Sagnik
• Is Part Of: Schizophrenia bulletin open. Volume 1:Issue 1(2020)
• Publication Date: 2020-04-20
• Subjects: resting state -- cannabis -- psychosis -- fMRI -- dorsal attention network -- visual network; Schizophrenia -- Periodicals; Schizophrenia -- Research -- Periodicals; Psychoses -- Periodicals; 616.898005
• DOI: 10.1093/schizbullopen/sgaa018
• Languages: English
• ISSNs: 2632-7899

Abstract

Abstract: Background: Both chronic cannabis use and psychotic disorders are associated with abnormalities in visual attentional processing. Using functional magnetic resonance imaging (fMRI), we sought to determine whether there would be a difference in functional connectivity in patients and controls with and without a history of cannabis use in the visual and dorsal attention networks. Methods: Resting-state fMRI data were acquired in patients with early psychosis with (EPC = 29) and without (EPNC = 25); and controls with (HCC = 16) and without (HCNC = 22) cannabis use. Results: There was a patient effect in both Visual-Dorsal Attention Internetwork ( F (1, 87) = 5.326, P = .023) and the Visual Network ( F (1, 87) = 4.044, P = .047) and a cannabis effect in the Dorsal Attention Network ( F (1, 87) = 4.773, P = .032). These effects were specific to the networks examined with no evidence for significant patient or cannabis effects in other canonical networks. Patients with a history of cannabis use showed increased connectivity in the Dorsal Attention Network (134%, P = .019) and Visual Dorsal Attention Internetwork (285%, P = .036) compared to non-using controls. In the EPC group connectivity of the Visual Network (ρ = 0.379, P = .042) and Visual-Dorsal Attention Internetwork (ρ = 0.421, P = .023) correlated with visual hallucinations which were significantly different from EPNC ( P = .011). Dorsal attention network strength correlated with severity of dependence for cannabis (ρ = 0.215, P = .04). Conclusion: We demonstrate specific cannabis and patient effects in networks associated with visual attentional processing. There is a differential association with hallucinatory symptoms in patients with and without a history of cannabis use. This may indicate that dysconnectivity in these networks serves different roles in the context of cannabis use.