A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses. (2001)

• Record Type: Journal Article
• Authors: Lara-Tejero Lara-Tejero, Maria Maria
• Is Part Of: TheScientificWorldjournal. Volume 1(2001)
• Page Start: 190
• Page End: 191
• Publication Date: 2001
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2001.27
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteristic of G2/M arrest [3]. The effect of the toxin on the cell is so striking that it captivated scientists for a long time. However, its mechanism of action had remained elusive.