Enhanced mechanical performance of biocompatible silk fibroin films through mesoscopic construction of hierarchical structures. Issue 9 (May 2021)

• Record Type: Journal Article
• Authors: Zhang, Yifan; Wu, Ronghui; Patil, Aniruddha; Ma, Liyun; Yu, Rui; Dong Yu, Wei; Yang Liu, Xiang
• Is Part Of: Textile research journal. Volume 91:Issue 9/10(2021)
• Page Start: 1146
• Page End: 1154
• Publication Date: 2021-05
• Subjects: silk fibroin -- hierarchical structures -- mechanical properties -- biodegradable film; Textile industry -- Periodicals; Textile fabrics -- Periodicals; Textile research -- Periodicals; Textiles et tissus -- Industrie et commerce -- Périodiques; Textiles et tissus -- Périodiques; Textiles et tissus -- Recherche -- Périodiques; Electronic journals; 677.005
• DOI: 10.1177/0040517520975622
• Languages: English
• ISSNs: 0040-5175

Abstract

Silk fibroin (SF) material receives a great deal of attention in the biomedical field for its extensive mechanical performance and applications due to its singular structure/properties and applications, especially hierarchical structure. Here, we blended polyethylene glycol (PEG) into SF solutions that reconstruct the hierarchical micro structure of SF. The effect of PEG on the SF gelation process was in situ observed through rheological measurement and optical density changes. The structural change of SF/PEG blended films with different concentrations and their effects on the mechanical performance were investigated. The results indicated that with increasing PEG content, the β-sheet content of the films increased with the α-helix declining, which enables a composite film with a fracture strain exceeding 300%, Young's modulus exceeding 200 MPa and a fracture strength exceeding 20 MPa. The culture of MC-3T3 proves that the film is beneficial for cell proliferation and adhesion. By constructing the mesoscopic structure of SF, the plasticized silk materials provide great options for biodegradable and flexible protein-based materials.