Tumour growth and immune evasion as targets for a new strategy in advanced cancer. Issue 11 (November 2018)

• Record Type: Journal Article
• Authors: Nicolini, Andrea; Ferrari, Paola; Rossi, Giuseppe; Carpi, Angelo
• Is Part Of: Endocrine-related cancer. Volume 25:Issue 11(2018)
• Page Start: R577
• Page End: R604
• Publication Date: 2018-11
• Subjects: breast cancer -- immune evasion -- tumour growth -- cancer therapy; Endocrine glands -- Cancer -- Periodicals; Endocrinology -- Periodicals; Cancer -- Endocrine aspects -- Periodicals; 616.9944005
• DOI: 10.1530/ERC-18-0142
• Languages: English
• ISSNs: 1351-0088

Abstract

Abstract : It has become clearer that advanced cancer, especially advanced breast cancer, is an entirely displayed pathological system that is much more complex than previously considered. However, the direct relationship between tumour growth and immune evasion can represent a general rule governing the pathological cancer system from the initial cancer cells to when the system is entirely displayed. Accordingly, a refined pathobiological model and a novel therapeutic strategy are proposed. The novel therapeutic strategy is based on therapeutically induced conditions (undetectable tumour burden and/or a prolonged tumour 'resting state'), which enable an efficacious immune response in advanced breast and other types of solid cancers.