Short Total Synthesis of Ajoene. Issue 38 (19th August 2018)

• Record Type: Journal Article
• Authors: Silva, Filipa; Khokhar, Shaista S.; Williams, Danielle M.; Saunders, Robert; Evans, Gareth J. S.; Graz, Michael; Wirth, Thomas
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 38(2018)
• Page Start: 12290
• Page End: 12293
• Publication Date: 2018-08-19
• Subjects: ajoene -- allicin -- garlic -- organosulfur compounds -- selenoxide elimination; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201808605
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable procedure for the synthesis of ajoene from simple building blocks that is also suitable for upscale operations. Abstract : Making garlic : An efficient total synthesis of ajoene from easily available starting materials is reported. Upscaling of the procedure enabled the synthesis of ajoene in larger amounts.