Serum interleukin-30 level in patients with psoriasis and its correlation with psoriasis severity: a case-control study. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Omar, Nergez Sabah; Long, Xinxin; Xian, Jiayi; Afewerky, Henok Kessete; Hussain, Saeed Ghulam; Peng, Xuebiao
• Is Part Of: Journal of international medical research. Volume 49:Issue 4(2021)
• Publication Date: 2021-04
• Subjects: Psoriasis -- interleukin-30 -- cytokine -- psoriasis pathogenesis -- Psoriasis Area and Severity Index -- inflammation; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/03000605211004039
• Languages: English
• ISSNs: 0300-0605

Abstract

Objectives: To examine the serum levels of interleukin (IL)-30 in patients with psoriasis and evaluate the correlations with the Psoriasis Area and Severity Index (PASI). Methods: Serum was collected from 26 patients with psoriasis and 26 healthy controls in a case–control setting, and the level of IL-30 was determined using an enzyme-linked immunosorbent assay. Statistical analysis of the IL-30 levels among groups and further correlation analyses of IL-30 levels with PASI scores were performed. Results: A significant increase in the level of IL-30 in patients with psoriasis compared with healthy controls was observed. In addition, a positive correlation between the IL-30 concentration and PASI scores was found in patients with psoriasis. Conclusion: IL-30 is presumably involved in the proliferation of epidermal cells during the development of psoriasis. Further studies with a larger number of participants are required to comprehensively elucidate the biological roles of IL-30 in the pathogenesis of psoriasis.