Association between post-balloon angioplasty dissection and primary patency in complex femoropopliteal artery disease: 2-year clinical outcomes of the AcoArt I trial. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Ren, Hao; Liu, Jie; Zhang, Jiwei; Zhuang, Baixi; Fu, Weiguo; Wu, Danming; Wang, Feng; Zhao, Yu; Guo, Pingfan; Bi, Wei; Wang, Shenming; Guo, Wei
• Is Part Of: Journal of international medical research. Volume 49:Issue 4(2021)
• Publication Date: 2021-04
• Subjects: Balloon angioplasty -- dissection -- femoropopliteal artery disease -- primary patency -- drug-coated balloon -- percutaneous transluminal angioplasty; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/03000605211006546
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: To assess the association between post-balloon angioplasty dissection and the mid-term results of the AcoArt I trial evaluating complex femoropopliteal artery disease. Methods: The outcome data for 144 patients from the AcoArt 1 trial were reanalysed. These patients were randomly divided into percutaneous transluminal angioplasty (PTA) and drug-coated balloons (DCB) groups. The primary endpoint was the primary patency (PP) rate and clinically-driven target lesion revascularisation at 24 months. Results: After 24 months of follow-up, the PP rate of dissection cases in the PTA group was lower vs non-dissection cases. In patients receiving a bailout stent for dissection, the PP rate in the PTA group was lower vs the DCB group. Cox regression analysis showed that dissection decreased the PP rate; mild dissection reduced the PP rate as follows: 52%, PTA group and 19%, DCB group. With severe dissection, the PP rate reduction was as follows: 75%, PTA group and 73%, DCB group. Conclusions: The mid-term follow-up showed that post-balloon angioplasty dissection reduced the PP rate in the PTA group but not in the DCB group. Additionally, in patients receiving a bailout stent for dissection, the DCB group had a better PP rate than the PTA group.