Declines in Lung Function After Antiretroviral Therapy Initiation in Adults With Human Immunodeficiency Virus and Tuberculosis: A Potential Manifestation of Respiratory Immune Reconstitution Inflammatory Syndrome. (25th September 2019)

• Record Type: Journal Article
• Authors: Auld, Sara C; Maenetje, Pholo; Ravimohan, Shruthi; Weissman, Drew; Ncube, Itai; Mlotshwa, Mandla; Ratsela, Nelly; Chase, William; Vangu, Mboyo-Di-Tamba; Wallis, Robert; Churchyard, Gavin; Kornfeld, Hardy; Bisson, Gregory P
• Is Part Of: Clinical infectious diseases. Volume 70:Number 8(2020)
• Page Start: 1750
• Page End: 1753
• Publication Date: 2019-09-25
• Subjects: tuberculosis -- HIV -- immune reconstitution inflammatory syndrome -- pulmonary function; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz733
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: End-organ impairment has received relatively little research attention as a possible manifestation of tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS). In this prospective cohort study, one-half of adults with human immunodeficiency virus and pulmonary tuberculosis experienced meaningful declines in lung function on antiretroviral therapy, suggesting a role for lung function in TB-IRIS definitions.