Lessons from isavuconazole therapeutic drug monitoring at a United Kingdom Reference Center. (12th May 2020)

• Record Type: Journal Article
• Authors: Borman, Andrew M; Hughes, Jessica M; Oliver, Debra; Fraser, Mark; Sunderland, Julie; Noel, Alan R; Johnson, Elizabeth M
• Is Part Of: Medical mycology. Volume 58:Number 7(2020)
• Page Start: 996
• Page End: 999
• Publication Date: 2020-05-12
• Subjects: Isavuconazole -- therapeutic drug monitoring -- LC-MS/MS -- drug concentrations -- accumulation; Medical mycology -- Periodicals; Veterinary mycology -- Periodicals; Mycology -- Periodicals; Mycoses -- Periodicals; Pathogenic fungi -- Periodicals; 616.969005
• DOI: 10.1093/mmy/myaa022
• Languages: English
• ISSNs: 1369-3786

Abstract

Abstract: We determined isavuconazole serum concentrations for 150 UK patients receiving standard isavuconazole dosing regimens, including serial therapeutic drug monitoring for several patients on prolonged therapy. Mean trough isavuconazole concentrations in these patients were virtually identical to those reported previously from clinical trials, although greater variability was seen in patients below 18 years of age. Serial monitoring in patients receiving prolonged therapy suggested gradual, near-linear accumulation of the drug over many weeks.