Novel vaterite-containing tricalcium silicate bone cement by surface functionalization using 3-aminopropyltriethoxysilane: setting behavior, in vitro bioactivity and cytocompatibility. (25th October 2017)

• Record Type: Journal Article
• Authors: Shu, Yan; Qiu, Fan; Zhang, Yin; Cao, Weijing; Wu, Zhenning; Nian, Shangjiu; Zhou, Nianying
• Is Part Of: Biomedical materials. Volume 12:Number 6(2017:Dec.)
• Publication Date: 2017-10-25
• Subjects: tricalcium silicate -- bone cement -- vaterite -- bioactive materials; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1088/1748-605X/aa84b8
• Languages: English
• ISSNs: 1748-6041

Abstract

Abstract: A novel vaterite-containing tricalcium silicate (V-C3 S) was grafted by 3-aminopropyltriethoxysilane (APTES), and the amino groups have been successfully fixed on the vaterite-containing tricalcium silicate powder's surface (after grafting the amino group, V-C3 S was named A-V-C3 S). The setting behavior, mechanical properties, porosity, weight loss and anti-washout properties of the tricalcium silicate (C3 S), V-C3 S and A-V-C3 S bone cement were systematically investigated. The in vitro induction of hydroxyapatite (HAp) formation of C3 S, V-C3 S and A-V-C3 S bone cement was confirmed by x-ray diffraction, Fourier-transform infrared spectroscopy and scanning electron microscopy. The cell viability, cell proliferation and cell attachment were investigated to assess the effects of bone cement on MC3T3-E1 cells. Results showed that the setting time of A-V-C3 S bone cement can meet the requirements of a clinical test, with improved anti-washout properties and an appropriate degradation rate. The pH value of the soaking solution was obviously decreased by surface modification. Besides, the morphology and fluorescence photograph results revealed that the A-V-C3 S bone cement showed an enhanced biocompatibility effect on the proliferation and attachment of MC3T3-E1 cells. The A-V-C3 S bone cement was expected to be a potential bone-substitute material.