Establishing correct kinetochore-microtubule attachments in mitosis and meiosis. Issue 2 (14th May 2020)

• Record Type: Journal Article
• Authors: Cairo, Gisela; Lacefield, Soni
• Editors: DeLuca, Jennifer; Fachinetti, Daniele; Dumont, Julien
• Is Part Of: Essays in biochemistry. Volume 64:Issue 2(2020)
• Page Start: 277
• Page End: 287
• Publication Date: 2020-05-14
• Subjects: aurora kinases -- Bub1 -- cellular reproduction -- Haspin kinase -- kinetochores -- meiosis; Biochemistry -- Periodicals; 572
• DOI: 10.1042/EBC20190072
• Languages: English
• ISSNs: 0071-1365

Abstract

Abstract: Faithful chromosome segregation in mitosis and meiosis requires that chromosomes properly attach to spindle microtubules. Initial kinetochore-microtubule attachments are often incorrect and rely on error correction mechanisms to release improper attachments, allowing the formation of new attachments. Aurora B kinase and, in mammalian germ cells, Aurora C kinase function as the enzymatic component of the Chromosomal Passenger Complex (CPC), which localizes to the inner centromere/kinetochore and phosphorylates kinetochore proteins for microtubule release during error correction. In this review, we discuss recent findings of the molecular pathways that regulate the chromosomal localization of Aurora B and C kinases in human cell lines, mice, fission yeast, and budding yeast. We also discuss differences in the importance of localization pathways between mitosis and meiosis.