Low salivary resolvin D1 to leukotriene B4 ratio predicts carotid intima media thickness: A novel biomarker of non-resolving vascular inflammation. (29th August 2020)

• Record Type: Journal Article
• Authors: Thul, Silke; Labat, Carlos; Temmar, Mohamed; Benetos, Athanase; Bäck, Magnus
• Is Part Of: European journal of preventive cardiology. Volume 24:Number 9(2017)
• Page Start: 903
• Page End: 906
• Publication Date: 2020-08-29
• Subjects: Atherosclerosis -- eicosanoids -- lipid mediators -- resolution of inflammation; Cardiovascular system -- Diseases -- Prevention -- Periodicals; Cardiac patients -- Rehabilitation -- Periodicals; 616.12
• DOI: 10.1177/2047487317694464
• Languages: English
• ISSNs: 2047-4873

Abstract

Abstract: Background: Different lipid mediators may have opposing effects on vascular inflammation. For example, whereas leukotriene B4 (LTB4 ) transduces inflammation, resolvin D1 (RvD1), which is synthesized from the omega-3 fatty acid docosahexaenoic acid, facilitates the resolution of inflammation. The aim of this study was to determine the association of the RvD1/LTB4 ratio with subclinical atherosclerosis. Methods: Saliva samples and ultrasound measurements of the intima media thickness of the carotid artery was obtained for 254 participants. The lipid mediators RvD1 and LTB4 were measured by enzyme-linked immunosorbent assay. Results: Participants with a salivary RvD1/LTB4 ratio >1 had a significantly lower intima media thickness than those in whom LTB4 prevailed. The salivary RvD1/LTB4 ratio independently predicted carotid intima media thickness. Conclusions: The ratio between the proresolving and proinflammatory salivary lipid mediators RvD1 and LTB4 may serve as a biomarker of non-resolving inflammation and its relation to intima media thickness in cardiovascular disease.