A strategy for imaging-guided cocktail cancer therapy using dual-colored polymeric drug carriers with amplified aggregation-induced emission behavior by donor–acceptor/Förster resonance energy transfer adjustment. Issue 23 (14th December 2020)

• Record Type: Journal Article
• Authors: Hua, Mengxia; Zhou, Yi; Wang, Ziyu; Wang, Cheng; Wang, Lu; Yuan, Hong; Hua, Daoben
• Is Part Of: Journal of materials research. Volume 35:Issue 23/24(2020)
• Page Start: 3286
• Page End: 3295
• Publication Date: 2020-12-14
• Subjects: biomaterial, -- polymer, -- nanoscale; Materials -- Research -- Periodicals; 620.1105
• DOI: 10.1557/jmr.2020.310
• Languages: English
• ISSNs: 0884-2914

Abstract

Abstract: Abstract : Nowadays, theranostics drug delivery systems (DDSs) with imaging and therapy bi-functions have been regarded as a future orientation for imaging-guided cancer therapy. To achieve high imaging quality, a donor–acceptor (D–A)/Förster resonance energy transfer (FRET) bi-adjustment strategy is carried out for designing dual-colored DDSs with amplified aggregation-induced emission (AIE) behavior for imaging-guided cocktail cancer therapy in this study. In detail, four AIE-active conjugated polymers P-1 to P-4 are synthesized via the Suzuki reaction. Noteworthily, the D–A-type structure is applied in tuning the fluorescence color from orange (P-1 ) to far-red/near-infrared (P-2 ), while the intramolecular FRET process further enhanced the fluorescence signal for six times (P-3 ). Afterwards, P-3 -based amphipathic polymer P-4 further acts as a drug carrier in preparing doxorubicin (Dox)- and curcumin (Cur)-loaded polymer dots (Pdots) (Dox-loaded Pdots as PDox and Cur-loaded Pdots as PCur). PDox + PCur DDS is successfully applied in imaging-guided cocktail cancer therapy to give obviously higher in vivo anticancer efficacy compared with single PDox or PCur. In addition, the drug-loaded Pdots also exhibit higher biocompatibility compared with free drugs. This work provides a novel D–A/FRET bi-adjustment strategy for developing high efficiency imaging-guided cocktail DDSs in cancer therapy.