Valganciclovir in pediatric organ transplantation. Issue 2 (April 2010)

• Record Type: Journal Article
• Authors: Pescovitz, Mark D
• Is Part Of: Pediatric health. Volume 4:Issue 2(2010)
• Page Start: 147
• Page End: 156
• Publication Date: 2010-04
• Subjects: children -- cytomegalovirus -- ganciclovir -- pharmacokinetics -- transplant -- valganciclovir; Pediatrics -- Periodicals; 618.920005
• DOI: 10.2217/phe.10.16
• Languages: English
• ISSNs: 1745-5111

Abstract

Valganciclovir has been used extensively for the prevention and treatment of cytomegalovirus in adults for many years. In August 2009, valganciclovir was approved by the US FDA for use in children at the same time as a valganciclovir oral solution. This oral solution will facilitate dosing in patients who are unable to swallow tablets or who require intermediate doses. This paper reviews the current status of the general use of valganciclovir in organ transplant patients with a particular focus on children. Valganciclovir appears to be safe and effective in children. The dose of valganciclovir that appears appropriate for children is based on both renal function and body surface area – specifically, dose (in mg) = seven-times the body surface area multiplied by the creatinine clearance (calculated using a modified Schwartz formula).