The metabolic aspects of polycystic ovary syndrome. (May 2011)

• Record Type: Journal Article
• Authors: Yasmin, Ephia; Balen, Adam H
• Is Part Of: Expert review of obstetrics & gynecology. Volume 6:Number 3(2011)
• Page Start: 331
• Page End: 341
• Publication Date: 2011-05
• Subjects: dyslipidemia -- insulin resistance -- metabolic syndrome -- polycystic ovary syndrome; Obstetrics -- Periodicals; Gynecology -- Periodicals; 618.05
• DOI: 10.1586/eog.11.18
• Languages: English
• ISSNs: 1747-4108

Abstract

Insulin resistance is considered to be a key pathophysiological feature of polycystic ovary syndrome (PCOS) but it is not essential to the diagnosis of the syndrome. However, insulin resistance underpins the metabolic profile found in PCOS, which includes dyslipidemia and impaired glucose tolerance. The metabolic features associated with PCOS, especially in the obese PCOS patient, form the metabolic syndrome. The major implications of these changes are the long-term consequences of Type 2 diabetes mellitus and cardiovascular risk. Therefore, identification of this risk and counseling of the patient in order to reduce future risk is essential. As obesity augments the risk of long-term consequences, weight loss and weight maintenance form the mainstay of treatment.