Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats. (29th December 2020)
- Record Type:
- Journal Article
- Title:
- Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats. (29th December 2020)
- Main Title:
- Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats
- Authors:
- Zhang, Yuxuan
Hao, Juan
Ma, Xuelian
Zhao, Qiyue
Gao, Xiaomeng
Wang, Xiangting
Xu, Qingyou - Other Names:
- Hu Weicheng Academic Editor.
- Abstract:
- Abstract : Objectives . To observe the effects of the Huoxue Jiedu Huayu Recipe (HJHR) on pyroptosis of glomerular mesangial cells in the contralateral unobstructed kidney (CK) of unilateral ureteral obstruction (UUO) rats. Methods . Sprague-Dawley rats were randomly divided into 4 groups: sham group, UUO group (10 days of left ureter ligation), UUO treated with eplerenone (EPL) (UUO + EPL) group, and UUO treated with HJHR (UUO + HJHR) group. The CKs of all rats were collected for studies. Results . Cell pyroptosis and macrophage infiltration was found in contralateral glomeruli, and nucleotide-binding oligomerization domain-like pyrin domain containing protein 3 (NLRP3) and interleukin (IL)-1 β expression was upregulated in the CK of UUO rats. All of these changes were inhibited by HJHR and eplerenone. To determine how aldosterone (Aldo) activated the mineralocorticoid receptor (MR) and then induced mesangial cell pyroptosis with NLRP3-caspase-1-IL-1 β pathway, human mesangial cells (HMCs) were treated with HJHR and eplerenone, which were examined to detect the expression of NLRP3 inflammasome-associated proteins following treatment with Aldo. Conclusion . These results suggest that HJHR and eplerenone suppressed HMC pyroptosis via the MR/NLRP3 pathway.
- Is Part Of:
- Evidence-based complementary and alternative medicine. Volume 2020(2020)
- Journal:
- Evidence-based complementary and alternative medicine
- Issue:
- Volume 2020(2020)
- Issue Display:
- Volume 2020, Issue 2020 (2020)
- Year:
- 2020
- Volume:
- 2020
- Issue:
- 2020
- Issue Sort Value:
- 2020-2020-2020-0000
- Page Start:
- Page End:
- Publication Date:
- 2020-12-29
- Subjects:
- Alternative medicine -- Periodicals
615.505 - Journal URLs:
- http://ecam.oupjournals.org ↗
http://www.ncbi.nlm.nih.gov/pmc/journals/241/ ↗
http://www.hindawi.com/journals/ecam/ ↗ - DOI:
- 10.1155/2020/2530431 ↗
- Languages:
- English
- ISSNs:
- 1741-427X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3831.036630
British Library HMNTS - ELD Digital store - Ingest File:
- 15415.xml