Fe3O4/TiO2 core/shell magnetic nanoparticle-based photokilling of pathogenic bacteria. (December 2010)

• Record Type: Journal Article
• Authors: Chen, Wei-Jen; Chen, Yu-Chie
• Is Part Of: Nanomedicine. Volume 5:Number 10(2010)
• Page Start: 1585
• Page End: 1593
• Publication Date: 2010-12
• Subjects: antibiotic-resistant -- magnetic nanoparticles -- pathogenic bacteria -- photokilling -- titania; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm.10.92
• Languages: English
• ISSNs: 1743-5889

Abstract

Aims: We demonstrate a photokilling approach for pathogenic bacteria using magnetic nanoparticles as photokilling nanoprobes.Materials & methods: The nanoprobes are composed of iron oxide/titania (Fe3 O4 /TiO2 ) core/shell magnetic nanoparticles. The titanium layer on the magnetic nanoprobes plays two roles: as a photokilling agent and as an affinity substrate for pathogenic bacteria. The magnetic property of the nanoprobes allows the resultant nanoprobe–target species conjugates to be readily aggregated at a small spot under external magnetic field for conducting photokilling treatment. Therefore, damage to nontarget cells can be reduced.Results: The results show that Fe3 O4 /TiO2 core/shell magnetic nanoparticles do not only have the capacity to target pathogenic bacteria, including Gram-negative, Gram-positive and antibiotic-resistant bacteria, but they can also be used to effectively inhibit the cell growth of the bacteria (>99.9%) targeted by the magnetic nanoparticles under irradiation of a low-power UV lamp (λmax ∼306 nm, 0.412 mW/cm 2 ) within 15 min.Conclusion: The potential application of this approach is in the treatment of cutaneous bacterial infections.