Hybrid Nanoreactors: Enabling an Off‐the‐Shelf Strategy for Concurrently Enhanced Chemo‐immunotherapy. (6th August 2018)

• Record Type: Journal Article
• Authors: Yang, Yannan; Tang, Jie; Abbaraju, Prasanna Lakshmi; Jambhrunkar, Manasi; Song, Hao; Zhang, Min; Lei, Chang; Fu, Jianye; Gu, Zhengying; Liu, Yang; Yu, Chengzhong
• Is Part Of: Angewandte Chemie. Volume 130:Number 36(2018)
• Page Start: 11938
• Page End: 11943
• Publication Date: 2018-08-06
• Subjects: Chemoimmuntherapie -- Immun-Checkpoint-Blockaden -- Immunogener Zelltod -- Immunsuppressive Tumoren -- Nanoreaktoren; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201807595
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for amplifying the immunogenic cell death and activating immune cells. A simple physical mixture of nanoreactors and chemodrugs in combination with immune checkpoint blockades show synergistically and concurrently enhanced chemo‐immunotherapy efficacy, inhibiting the growth of both treated primary immunosuppressive tumors and untreated distant tumors. The off‐the‐shelf strategy uses tumor antigens generated in situ and avoids cargo loading, and is thus a substantial advance in personalized nanomedicine for clinical translation.