The Status of Vaccine Development Against the Human Cytomegalovirus. (5th March 2020)

• Record Type: Journal Article
• Authors: Plotkin, Stanley A; Wang, Dai; Oualim, Abdel; Diamond, Don J; Kotton, Camille N; Mossman, Sally; Carfi, Andrea; Anderson, David; Dormitzer, Philip R
• Is Part Of: Journal of infectious diseases. Volume 221(2020)Supplement 1
• Page Start: S113
• Page End: S122
• Publication Date: 2020-03-05
• Subjects: cytomegalovirus -- fetal infection -- organ transplant -- stem cell transplant; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiz447
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Numerous candidate vaccines against cytomegalovirus (CMV) infection and disease are in development. Whereas the previous article [1 ] provides background and opinions about the issues relating to vaccination, this article provides specifics about the vaccines in active development, as reported at a National Institutes of Health-sponsored meeting in Bethesda on September 4–6, 2018. Here, vaccine developers provide synopses of their candidate vaccines to immunize women to protect against congenital CMV disease and to prevent the consequences of CMV disease in recipients of transplanted organs or hematopoietic stem calls. The projects are presented here roughly in the descending order of their stage of development in the opinion of the first author.